Akira Kudo, PhD.
Professor, Department of Biological Information
Office: Room 601, B1 building, Suzukakedai campus
Areas of Research: Bone development and remodeling
Keywords: Medaka, Osteoblast, Osteoclast, Space, periostin
We have been studying the molecular system of bone formation and remodeling employing medaka as an animal model, and performed the next 4 projects.
- To find the mechanism of pattern formation for vertebral bone during development
- To find the collaboration of osteoblasts and osteoclasts in bone remodeling
- To reveal the mechanism of bone loss under microgravity
- To find the function of periostin in fin development and regeneration
- Takeyama, K., Chatani, M., Takano, Y. and Kudo, A. In-vivo imaging of the fracture healing in medaka revealed two types of osteoclasts before and after the callus formation by osteoblasts. Dev. Biol. doi: 10.1016/j.ydbio.2014.08.007
- Iida, Y., Hibiya, K., Inohaya, K. and Kudo, A. Eda/Edar signaling guides fin ray formation with preceding osteoblast differentiation, as revealed by analyses of the medaka all-fin less mutant afl. Dev. Dyn. 243: 765-777 (2014)
- Conway, S. J.,Izuhara, K., Kudo, y., Litvin, J., Markwald, R., Ouyang, G., Arron, J. R., Holweg, C. T. J., and Kudo, A. The role of periostin in tissue remodeling across health and disease. Cell. Mol. Life Sci. 71: 1279-1288 (2014)
- Ito, N., Ruegg, U. T., Kudo, A., Miyagoe-Suzuki, Y. and Takeda S. NO/peroxynitrite-induced activation of TRPV1: A pivotal role of calcium signaling in skeletal muscle hypertrophy. Nat. Med. 19: 101-106 (2013)
- Fujita, M., Mitsuhashi, H., Isogai, S., Nakata, T., Kawakami, A., Nonaka, I., Noguchi, S., Hayashi, Y. K., Nishino, I. and Kudo, A. Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro. Dev. Biol. 361: 79-89 (2012)
- Chatani, M., Takano, Y. and Kudo, A. Osteoclasts in bone modeling, as revealed by in vivo imaging, are essential for organogenesis in fish. Dev. Biol. 360: 96-109 (2011)
Associate Professor, Department of Biological Information
PhD 1990, Nagoya University
Office: Room 602, bldg. B1, Suzukake-dai Campus
Areas of Research: Regenerative Biology, Developmental Biology.
Keywords: Tissue regeneration, Zebrafish.
Most multicellular organisms have inherence shapes and sizes that do not change throughout lives. Such a robust capacity for maintaining bodies and organs is called the tissue homeostasis. This mechanism enables us to survive for a long time in spite of continuous damages and exhaustion of cells and organs. Though we humans always turn over the cells that constitute our body, we cannot reform a loss of large tissue parts such as arms and legs. However, urodeles and fish have a remarkable ability of tissue homeostasis and regenerate the lost body parts such as fins. Surprisingly, they regenerate not only the appendages like fins and scales, but they also regenerate the heart, brain, eye and many of the internal organs. Considering the conservation of most of genes and signaling networks during evolution, the difference of regeneration abilities between species possibly depends on the subtle changes of gene function and/or expression.
Our lab is focusing to reveal the process of tissue regeneration at molecular and cellular level using zebrafish as a model. We would like to identify the cells, their interactions and involved molecular signals that make tissue regeneration possible. By reproducing an appropriate condition for tissue regeneration, we will be able to regain regeneration ability in many of our organs.
- Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K. and *Kawakami, A. (2016) Fgf signalling controls diverse aspects of finregeneration. Development 143, 2920-2929. Doi:10.1242/dev.140699
- Hasegawa, T., Nakajima, T., Ishida, T. Kudo, A. and *Kawakami, A. (2015) A diffusible signal derived from hematopoietic cells supports 3the survival and proliferation of regenerative cells during zebrafish fin fold regeneration. Developmental Biology 399, 80-90.
- Yoshinari, N., Ando, K., Kudo, A., Kinoshita, M. and *Kawakami, A. (2012) Colored medaka and zebrafish: Transgenics with ubiquitous andstrong transgene expression driven by the medakab-actin promoter. Development Growth & Differentiation 54, 818-828.
- Ishida, T., Nakajima, T., Kudo, A. and * Kawakami, A. (2010) Phosphorylation of Junb family proteins by the Jun N-terminal kinasesupports tissue regeneration in zebrafish. Developmental Biology 340, 468-479.
- (REVIEW) *Kawakami, A. (2010) Stem cell system in tissue regeneration in fish. Development Growth & Differentiation 52, 77-87.
- Yoshinari, N., Ishida, T., Kudo, A., and *Kawakami, A. (2009) Gene expression and functional analysis of zebrafish larval fin foldregeneration. Developmental Biology 325, 71-81.