研究成果

【代表論文】

  • [1] Multiple regulation of rad51-mediated homologous recombination by fission yeast fbh1. Tsutsui Y, Kurokawa Y, Ito K, Siddique MS, Kawano Y, Yamao F and Iwasaki H. PLoS Genet. (2014) 28. e1004542.
  • [2] Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition. Murayama Y, Kurokawa Y, Tsutsui Y, Iwasaki H. Genes Dev. (2013) 27:2299-2304.
  • [3] Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex. Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H and Shimizu T. Structure (2012) 20:440-449.
  • [4] An in vitro assay for monitoring the formation and branch migration of Holliday junctions mediated by a eukaryotic recombinase. Murayama Y and Iwasaki H. Methods Mol. Biol. (2011) 745:385-405.
  • [5] The fission yeast meiosis-specific Dmc1 recombinase mediates formation and branch migration of Holliday junctions by preferentially promoting strand-exchange in a direction opposite to that of Rad51. Murayama Y, Tsutui, Y and Iwasaki H. Genes Dev. (2011) 25:516-527.
  • [6] Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Williams RS, Dodson GE, Limbo O, Yamada Y, Williams JS, Guenther G, Classen S, Glover JN, Iwasaki H, Russell P and Tainer JA. Cell (2009) 139: 87-99.
  • [7] RAD6-RAD18-RAD5 pathway-dependent tolerance to chronic low-dose UV light. Hishida T, Kubota Y, Carr AM, and Iwasaki H. Nature (2009) 457: 612-615.
  • [8] Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double strand break repair in association with the Mre11-Rad50-Nbs1 complex. Akamatsu Y, Murayama Y, Yamada T, Nakazaki T, Tsutsui Y, Ohta K and Iwasaki H. Mol. Cell. Biol. (2008) 28: 3639-3651.
  • [9] Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators. Kurokawa Y, Murayama Y, Haruta-Takahashi N, Urabe I and Iwasaki H. PLoS Biol (2008) 6: e88.
  • [10] Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases. Murayama Y, Kurokawa Y, Mayanagi K and Iwasaki H. Nature (2008) 451: 1018-1021.
  • [11] Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes. Akamatsu Y, Tsutsui Y, Morishita T, Siddique, MDP, Kurokawa, Y. Ikeguchi M, Yamao F, Arcangioli B and Iwasaki H. EMBO J. (2007) 26: 1352-1362.
  • [12] The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro. Haruta N, Kurokawa Y, Murayama Y, Akamatsu Y, Unzai S, Tsutsui Y and Iwasaki H. Nature Struct. Mol. Biol. (2006) 13: 823-730.
  • [13] Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast. Akamatsu Y, Dziadkowiec D, Ikeguchi M, Shinagawa H and Iwasaki H. Proc. Natl. Acad. Sci. USA. (2003) 100: 15770-15775.
  • [14] Atomic structure of the RuvC resolvase: a Holliday junction specific endonuclease from E. coli. Ariyoshi M, Vassylyev DG, Iwasaki H, Nakamura H, Shinagawa H and Morikawa K. Cell (1994) 78: 1063-1072.
  • [15] Escherichia coli RuvA and RuvB proteins specifically interact with Holliday junctions and promote branch migration. Iwasaki H, Takahagi M, Nakata A and Shinagawa H. Genes Dev.i (1992) 6: 2214-2220.
  • [16] Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure. Iwasaki H, Takahagi M, Shiba T, Nakata A and Shinagawa H. EMBO J. (1991) 10: 4381-4389.

【主な著書】

  • [1] 岩崎博史、田口英樹 著「池上彰が聞いてわかった生命のしくみ ー東工大で生命科学を学ぶー」 朝日新聞出版(2016)

ページ上部へ