研究成果

【代表論文】

  • [1] Mochida, K., Oikawa, Y., Kimura, Y., Kirisako, H., Hirano, H., Ohsumi, Y., Nakatogawa, H.* Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature 522, 359-362. (2015)
  • [2] Mochida, K., Ohsumi, Y., Nakatogawa, H. Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions. FEBS Lett. 588, 3862-3869. (2014)
  • [3] Tanaka, C., Tan, L.J., Mochida, K., Kirisako, H., Koizumi, M., Asai, E., Sakoh-Nakatogawa, M., Ohsumi, Y., Nakatogawa, H. Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins. J. Cell Biol. 207, 91-105. (2014)
  • [4] Sakoh-Nakatogawa, M., Matoba, K., Asai, E., Kirisako, H., Ishii, J., Noda, N.N., Inagaki, F., Nakatogawa, H.*, Ohsumi, Y.* Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Nat. Struct. Mol. Biol. 20, 433-439. (2013)
  • [5] Nakatogawa, H.* Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy. Essays Biochem. (Review) 55, 39-50. (2013)
  • [6] Yamaguchi, M., Matoba, K., Sawada, R., Fujioka, Y., Nakatogawa, H., Yamamoto, H., Kobashigawa, Y., Hoshida, H., Akada, R., Ohsumi, Y., Noda, N.N., Inagaki, F. Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Nat. Struct. Mol. Biol. 19, 1250-1256. (2012)
  • [7] Nakatogawa, H.*, Ohsumi, Y. SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy. Methods Mol. Biol. (Review) 832, 519-529. (2012)
  • [8] Nakatogawa, H.*, Ohbayashi, S., Sakoh-Nakatogawa, M., Kakuta, S., Suzuki, S.W., Kirisako, H., Kondo-Kakuta, C., Noda, N.N., Yamamoto, H., Ohsumi, Y. The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation. J. Biol. Chem. 287, 28503-28507. (2012)
  • [9] Nakatogawa, H.*, Ishii, J., Asai, E., Ohsumi, Y.* Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy 8, 177-186. (2012)
  • [10] Noda, N.N., Satoo, K., Fujioka, Y., Kumeta, H., Ogura, K., Nakatogawa, H., Ohsumi, Y., Inagaki, F. Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol. Cell 44, 462-475. (2011)
  • [11]  Nakatogawa, H., Suzuki, K., Kamada, Y., Ohsumi, Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat. Rev. Mol. Cell Biol. (Review) 10, 458-467. (2009)
  • [12] Noda, N.N.#, Kumeta, H.#, Nakatogawa, H.# (# these authors contributed equally to this work), Satoo, K., Adachi, W., Ishii, J., Fujioka, Y., Ohsumi, Y., Inagaki, F. Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 13, 1211-1218. (2008)
  • [13] Oh-oka, K., Nakatogawa, H., Ohsumi, Y. Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8. J. Biol. Chem. 283, 21847-21852. (2008)
  • [14] Nakatogawa, H., Ichimura, Y., Ohsumi, Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130, 165-178. (2007)
  • [15] Muto, H., Nakatogawa, H., Ito, K. Genetically encoded but non-polypeptide prolyl-tRNA functions in the A-site for SecM-mediated ribosomal stall. Mol. Cell 22, 545-552. (2006)
  • [16] Nakatogawa, H., Murakami, A., Mori, H., Ito, K. SecM facilitates translocase function of SecA by localizing its biosynthesis. Genes Dev. 19, 436-444. (2005)
  • [17] Murakami, A., Nakatogawa, H., Ito, K. Translation arrest of SecM is essential for the basal and regulated expression of SecA. Proc. Natl. Acad. Sci. USA 101, 12330-12335. (2004)
  • [18] Nakatogawa, H., Ito, K. The ribosomal exit tunnel functions as a discriminating gate. Cell 108, 629-636. (2002)
  • [19] Nakatogawa, H., Ito, K. Secretion monitor, SecM, undergoes self translation arrest in the cytosol. Mol. Cell 7, 185-192. (2001)

【主な日本語総説】

  • [1] 中戸川 仁、大隅 良典 「酵母が映し出すオートファゴソーム形成機構の最新像と未解決の重要課題」 命名から50年 オートファジーで解明した謎,解明したい謎 実験医学 31, 1348-1354. (2013)
  • [2] 中戸川 仁、大隅 良典 「オートファジーにおける膜形成のダイナミクスと分子メカニズム」 実験医学 増刊 タンパク質分解系による生体制御 29, 120-126. (2011)

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