研究成果

【代表論文】

  • [1] N. Shimada, M. Saito, S. Shukuri, S. Kuroyanagi, T. Kuboki, S. Kidoaki, T. Nagai, and A. Maruyama, Reversible Monolayer/Spheroid Cell Culture Switching by UCST-Type Thermoresponsive Ureido Polymers, ACS Appl. Mater. Inter. 8, 31524-31529. (2016)
  • [2] K. Saito, N. Shimada, A. Maruyama, Cooperative enhancement of deoxyribozyme activity by chemical modification and added cationic copolymer, Sci. Tech. Adv. Mater. 17,437-442.(2016)
  • [3] N. Shimada, H. Kinoshita, S. Tokunaga, T. Umegae, N. Kume, W. Sakamoto, A. Maruyama, Inter-polyelectrolyte nano-assembly induces folding and activation of functional peptides, J. Control. Release, 218, 45-52 (2015)
  • [4] J. Gao, N. Shimada, A. Maruyama, Enhancement of deoxyribozyme activity by cationic copolymers, Biomater. Sci., 3, 308-316 (2015)
  • [5] N. Shimada, S. Kidoaki, A. Maruyama, Smart hydrogels exhibiting UCST-type volume changes under physiologically relevant conditions, RSC Advances, 4, 52346-52348 (2014)
  • [6] A. Maruyama, N. Sonda, K. Yamasaki, M. Hirano, S. Kidoaki, N. Shimada, M. Maeshiro, M. Miyazaki, Cationic Comb-Type Copolymer Excludes Intercalating Dye from DNA Without Inducing DNA Condensation. Curr. Nanosci., 10, 185-188 (2014)
  • [7] N. Shimada, M. Nakayama, A. Kano, A. Maruyama,Design of UCST Polymers for Chilling Capture of Proteins, Biomacromolecules, 14 , 1452-1457 (2013)
  • [8] J. Du, L. Wu, N. Shimada, A. Kano, A. Maruyama, Polyelectrolyte-Assisted Transconformation of Stem-loop DNA, Chem. Commun., 49, 475-477 (2013)
  • [9] H. Asanuma, T. Osawa, H. Kashida, T. Fujii, X. Liang, K. Niwa, Y.Yoshida, N. Shimada, A. Maruyama, A polycation-chaperoned in-stem molecular beacon system, Chem. Commun., 48, 1760 -1762, (2012)
  • [10] R. Moriyama, N. Shimada, A. Kano, A. Maruyama, The Role of Cationic Comb-type Copolymers in Chaperoning DNA Annealing. Biomaterials, 32, 7671-7676 (2011)
  • [11] N. Shimada, H. Ino, K. Maie, M. Nakayama, A. Kano, A. Maruyama, Ureido-Derivatized Polymers Based on Both Poly(allylurea) and Poly(L-citrulline) Exhibit UCST-Type Phase Transition Behavior under Physiologically Relevant Conditions. Biomacromolecules, 10, 3418-3422 (2011)
  • [12] N. Shimada , M. Yamamoto, A.Kano , and A. Maruyama, Cationic Graft Copolymer as a DNA B-Z Transition Inducer: Effect of Copolymer Structure. Biomacromolecules, 11, 11, 3043-3048 (2010)
  • [13] S. Mochizuki, A. Kano, N. Shimada, A. Maruyama, Uptake of enzymatically-digested hyaluronan by endothelial liver cells in vivo and in vitro. J. Biomater. Sci. Polymer Edn., 20, 83-97 (2009)
  • [14] N. Shimada, A. Kano and A. Maruyama, B-Z DNA Transition Triggered by a Cationic Comb-Type Copolymer. Adv. Funct. Mater., 19, 3590-3595 (2009)
  • [15] S. W. Choi, A. Kano and A. Maruyama, Activation of DNA strand exchange by cationic comb-type copolymers: effect of cationic moieties of the copolymers. Nucleic Acids Res., 36, 342-351 (2008)
  • [16]  A. Maruyama, L. Wu, N. Shimada and A. Kano, Kinetic Effect of Cationic Comb-type Copolymers on DNA Hybridization, Adv. Mater. Res., 47-50, 1355-1358 (2008)
  • [17] N. Makita, S. W. Choi, A. Kano, A. Yamayoshi, T. Akaike, A. Maruyama, Effect of cationic copolymer on quadruplex folding of human telomeric DNA, Nucleosides, Nucleotides Nucleic Acids, 26, 1115-1119 (2007)
  • [18] Y. Sato, R. Moriyama, S. W. Choi, A. Kano, A. Maruyama, Spectroscopic investigation of cationic comb-type copolymers/DNA interaction: interpolyelectrolyte complex enhancement synchronized with DNA hybridization. Langmuir, 23, 65-69 (2007).
  • [19] T. Ooya, H. S. Choi, A. Yamashita, N. Yui, Y. Sugaya, A. Kano, A. Maruyama, H. Akita, K. Kogure, H. Harashima, Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery, J. Am. Chem. Soc., 128, 3852-3853 (2006).
  • [20] Y. Sato, Y. Kobayashi, T. Kamiya, H. Watanabe, T. Akaike, K. Yoshikawa, A. Maruyama, The effect of backbone structure on polycation comb-type copolymer/DNA interactions and the molecular assembly, Biomaterials, 26, 703-11 (2005).
  • [21] W. J. Kim, Yuichi Sato, Toshihiro Akaike, Atsushi Maruyama, Cationic comb-type copolymers for DNA analysis, Nature Mater., 2, 815-820 (2003)
  • [22] W. J. Kim, T. Akaike, A. Maruyama, DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer, J. Am. Chem. Soc., 124, 12676-12677 (2002).
  • [23] S. Asayama, T. Akaike, A. Maruyama, Bi-phaseic polycation for the DNA carrier responding to endosomal pH, Colloids Surf. B., 22, 183-191 (2001).
  • [24] A. Ferdous, T. Akaike, A. Maruyama, Mechanism of intermolecular purine-purine-pyrimidine triple helix stabilization by comb-type polylysine graft copolymer at physiologic potassium concentration, Bioconjugate Chem., 11, 520-526 (2000).
  • [25] A. Maruyama, H. Watanabe, A. Ferdous, M. Katoh, T. Ishihara, T. Akaike, Characterization of interpolyelectrolyte complexs between double-stranded DNA and polylysine comb-type copolymers having hydrophilic side chains, Bioconjugate Chem., 9, 292-299 (1998)

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