研究成果

【代表論文】

二酸化炭素を利用する酵素反応による有用物質の有機合成

  • [1] Stabilization of pyruvate decarboxylase under pressurized carbon dioxide and water biphasic system, T. Matsuda, K. Nakayama, T. Abe, M. Mukouyama, Biocatal. Biotrans. 2010, 28, 167-171.
  • [2] High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide, T. Matsuda, K. Watanabe, T. Harada, K. Nakamura, Y. Arita, Y. Misumi, S. Ichikawa, T. Ikariya, Chem. Commun. 2004, 2286-2287.

アルコール脱水素酵素を利用する有用物質の有機合成

  • [1] Acetophenone reductase with extreme stability against a high concentration of organic compounds or an elevated temperature, T. Yamamoto, Y. Naakata, C. Cao, Y. Sugiyama, Y. Asanuma, S. Kanamaru, T. Matsuda, Appl. Microbiol. Biotechnol. 2013, 2013, 97, 10413-10421.
  • [2] Purification and characterization of fluorinated ketone reductase from Geotrichum candidum NBRC 5767, C. Cao, T. Fukae, T. Yamamoto, S. Kanamaru, T. Matsuda, Biochem. Eng. J. 2013, 76, 13-16.
  • [3] Two classes of enzymes of opposite stereochemistry in an organism: one for fluorinated and another for non-fluorinated substrates, T. Matsuda, T. Harada, N. Nakajima, T. Itoh, K. Nakamura, J. Org. Chem. 2000, 65, 157-163.

【主な日本語総説】

  • 12節 超臨界二酸化炭素を溶媒に用いた酵素反応, 松田知子, 新しい溶媒を用いた有機合成, S&T出版株式会社, 2013, p.109-119.

【著書】

  • [1] Future directions in biocatalysis, T. Matsuda, Ed. Elsevier, Amsterdam, 2007.
  • [2] Biocatalytic asymmetric reduction of C=O and activated C=C bonds in stereoselective synthesis, T. Matsuda, R. Yamanaka, K. Nakamura, In Stereoselective synthesis of drugs and natural products, Eds. V. Andrushko, N. Andrushko, Wiley, 2013, p. 2015-1042.

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