研究成果

【代表論文】

  • [1] K. Fukunaga, H. Tsutsumi, H. Mihara. Cell Differentiation on Disk- and String-Shaped Hydrogels Fabricated from Ca2+-responsive Self-Assembling Peptides. Biopolymers (Pept. Sci), 2016, 106, 476-483.
  • [2] H. Tsutsumi, K. Nakano, H. Mihara. Dihydrofolate Reductase Inhibitory Peptides Screened from a Structured Design β-Loop Peptide Library Displayed on Phage. Mol. BioSyst., 2015, 11, 2713-2716.
  • [3] J. Yang, T. Furuta, M. Sakurai, H. Tsutsumi, H. Mihara. A Computational Study of the Interaction of Amphiphilic α-Helical Cell-Penetrating Peptides with Heparan Sulfate. Bull. Chem. Soc. Jpn., 2014, 87, 1074-1082.
  • [4] K. Usui, T. Kikuchi, K. Kikuchi, M. Mie, E. Kobatake, H. Mihara. Cellular Differentiation Assessments by Measuring the Degree of Cellular Internalization and Membrane Adsorption Using Designed Peptides. Bioorg Med Chem Lett, 2014, 24, 4129-4131.
  • [5] J. Yang, H. Tsutsumi, T. Furuta, M. Sakurai, H. Mihara. Interaction of Amphiphilic α-Helical Cell-Penetrating Peptides with Heparan Sulfate. Org. Biomol. Chem., 2014, 12, 4673-4681.
  • [6] H. Park, H. Tsutsumi, H. Mihara. Cell-Selective Intracellular Drug Delivery Using Doxorubicin and α-Helical Peptides Conjugated to Gold Nanoparticles. Biomaterials, 2014, 35, 3480-3487.
  • [7] K. Usui, T. Kikuchi, KY. Tomizaki, T. Kakiyama, H. Mihara. A Novel Array Format for Monitoring Cellular Uptake Using a Photo-Cleavable Linker for Peptide Release. Chem. Commun., 2013, 49, 6394-6396.
  • [8] H. Tsutsumi, H. Mihara. Self-Assembly of Designed Peptides and Their Nanomaterials Applications. Amino Acids, Peptides and Proteins, ed. E. Farkas and M. Ryadnov, Royal Society of Chemistry Publishing, Cambridge, UK, 2013, vol. 38, pp. 122–150.
  • [9] H. Tsutsumi, H. Mihara. Soft Materials Based on Designed Self-Assembling Peptides: from Design to Application. Mol. BioSyst., 2013, 9, 609-617.
  • [10] K. Fukunaga, H. Tsutsumi, H. Mihara. Self-Assembling Peptide Nanofibers Promoting Cell Adhesion and Differentiation. Biopolymers (Pept. Sci), 2013, 100, 731-737.
  • [11] K. Arai, H. Tsutsumi, H. Mihara. A Monosaccharide-Modified Peptide Phage Library for Screening of Ligands to Carbohydrate-Binding Proteins. Bioorg. Med. Chem. Lett., 2013, 23, 4940-4943.
  • [12] H. Park, H. Tsutsumi, H. Mihara. Cell Penetration and Cell-Selective Drug Delivery Using α-Helix Peptides Conjugated with Gold Nanoparticles. Biomaterials, 2013, 34, 4872-4879.
  • [13] K. Usui, T. Kikuchi, M. Mie, E. Kobatake, H. Mihara. Systematic Screening of the Cellular Uptake of Designed Alpha-Helix Peptides. Bioorg. Med. Chem., 2013, 21, 2560-2567.
  • [14] H. Tsutsumi, H. Ohkusa, H. Park, T. Takahashi, H. Yuasa, H. Mihara. Gold Nanoparticles Conjugated with Monosaccharide-modified Peptide for Lectin Detection. Bioorg. Med. Chem. Lett., 2012, 22, 6825-6827.
  • [15] T. Sawada, M. Tsuchiya, T. Takahashi, H. Tsutsumi, H. Mihara. Cell-Adhesive Hydrogels Composed of Peptide Nanofibers Responsive to Biological Ions. Polymer J., 2012, 44, 651-657.
  • [16] T. Sawada, H. Mihara. Dense Surface Functionalization Using Peptides that Recognize Differences in Organized Structures of Self-assembling Nanomaterials. Mol. BioSyst., 2012, 8, 1264-1274.
  • [17] A. Syahir, K. Kajikawa, H. Mihara. Sensitive Detection of Small Molecule-Protein Interactions on a Metal-Insulator-Metal Label-Free Biosensing Platform. Chem. Asia. J., 2012, 7, 1867-1874.
  • [18] K. Usui, T. Kakiyama, K. Tomizaki, M. Mie, E. Kobatake, H. Mihara. Cell Fingerprint Patterns Using Designed α-Helical Peptides to Screen for Cell-Specific Toxicity. Bioorg. Med. Chem. Lett., 2011, 21, 6281-6284.
  • [19] T. Sawada, K. Ishiguro, T. Takahashi, H. Mihara. A Novel β-loop Scaffold of Phage-Displayed Peptides for Highly Specific Affinities. Mol. BioSyst., 2011, 7, 2558-2562.
  • [20] A. Miyachi, T. Takahashi, S. Matsumura, H. Mihara. Peptide Nanofibers Modified with a Protein by Using Designed Anchor Molecules Bearing Hydrophobic and Functional Moieties. Chem. Eur. J., 2010, 16, 6644-6650.
  • [21] T. Sawada, T. Takahashi, H. Mihara. Affinity-Based Screening of Peptides Recognizing Assembly States of Self-Assembling Peptide Nanomaterials. J. Am. Chem. Soc., 2009, 131, 14434-14441.
  • [22] K. Usui, K.-Y. Tomizaki, H. Mihara. Screening of α-Helical Peptide Ligands Controlling a Calcineurin-phosphatase Activity. Bioorg. Med. Chem. Lett., 2007, 17, 167-17
  • [23] S. Matsumura, S. Uemura, H. Mihara. Metal-triggered Nanofiber Formation of His-containing β-sheet Peptide. Suplamolc. Chem., 2006, 18, 397-403.
  • [24] K. Usui, T. Ojima, K.-Y. Tomizaki,, H. Mihara. A Designed Glycopeptide Array for Characterization of Sugar-Binding Proteins Toward a Glycopeptide Chip Technology. NanoBiotechnology, 2005, 1, 191-200.
  • [25] S. Matsumura, S. Uemura, H. Mihara. Construction of biotinylated peptide nanotubes for arranging proteins. Mol. BioSyst., 2005, 1, 146-148.

【著書】

  • [1] 堤浩、三原久和 第Ⅰ編 第2章 自己組織化現象を利用したペプチド性足場材料の開発 再生医療用足場材料の開発と市場、2016年、シーエムシー出版
  • [2] 臼井健二、堤浩、三原久和 第2章 タンパク質チップ, ペプチドチップ. 9. 生体分子解析・細胞解析に向けた設計ペプチドチップ、伊藤嘉浩 監修、バイオチップの基礎と応用-原理から最新の研究・開発動向まで-、2015 年、シーエムシー出版
  • [3] 三原久和 設計ペプチドライブラリーを利用するタンパク質・細胞分析チップ. 最新ペプチド合成技術とその創薬研究への応用、メディカルドウ、2012年、323-238
  • [4] 臼井健二、富崎欣也、三原久和 “オミクス”研究に向けた設計ペプチドアレイの構築. 分析化学、2012年、61(6)、523-534
  • [5] 臼井健二、菊池卓哉、三原久和 タンパク質・細胞分析用デザインペプチドチップ. シングルセル解析の最前線(神原秀記、松永是、植田充美監修)、シーエムシー出版、2010年、17-24

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