研究成果

【代表論文】

  • [1] Onimaru, K., Marcon, L., Musy, M., Tanaka, M., Sharpe, J. The fin to limb transition as the re-organisation of a Turing pattern. Nature Communications 7, Article number 11582 (2016)
  • [2] Tanaka, M. Fins into limbs: autopod acquisition and anterior elements reduction by modifying gene networks involving 5’Hox, Gli3 and Shh. Dev. Biol. 413, 1-7 (2016)
  • [3] Onimaru, K., Kuraku, S., Takagi, W., Hyodo, S., Sharpe, J., Tanaka, M. A shift in anterior-posterior positional information underlies the fin-to-limb evolution. eLife 4, e07048 (2015)
  • [4] Suda, N., Ito, T., Nakato, R., Shirakawa, D., Bando, M., Katou, Y.,Kataoka, K., Shirahige, K., Tickle, C., Tanaka, M.* Dimeric combinations of MafB, cFos, and cJun control the apoptosis-survival balance in limb patterning. Development 141, 2885-2894 (2014)
  • [5] Tanaka, M.* Acquisition of the paired fins: a view from the sequential evolution of the lateral plate mesoderm. Evol. Dev. 109, 8937-8942 (2012)
  • [6] Hosokawa, Y.*, Ochi, H., Iino, T., Hiraoka, A., Tanaka, M.* Photophoration of biomolecules into single cells in living vertebrate embryos induced by a femtosecond laser amplifier. PLoS ONE 6, e27677 (2011)
  • [7] Onimaru, K.*, Shoguchi, E., Kuratani, S., Tanaka, M.* Development and evolution of the lateral plate mesoderm: Comparative analysis of amphioxus and lamprey with implications for the acquisition of paired fins. Dev. Biol. 359, 124-136 (2011)
  • [8] Murakami, Y. *, Tanaka, M. * Evolution of motor innervation to fins and limbs. Dev. Biol. 355, 164-172 (2011).
  • [9] Tanaka, M.* Revealing the mechanisms of rostral shift of pelvic fins among teleost fishes. Evol. Dev. 13, 380-388 (2011)
  • [10] Murata, Y., Tamura, M., Aita, Y., Murakami, Y., Fujimura, K., Okabe, M., Okada, N., Tanaka, M.* Allometric growth of the trunk leads to the rostral shift of the pelvic fin in teleost fishes. Dev. Biol. 347, 236-245 (2010)
  • [11] Kokubo N., Matsuura, M., Onimaru, K., Ticke, E., Kuraku, S., Kuratani, S., Tanaka, M.* Mechanisms of heart development in the Japanese lamprey, Lethenteron japonicum. Evol. Dev. 12, 34-44 (2010)
  • [12] Sakamoto, K., Onimaru, K., Munakata, K., Suda, N., Tamura, M., Ochi, H., Tanaka, M.* Heterochronic shift in Hox-mediated activation of Sonic hedgehog leads to morphological changes during vertebrate fin evolution. PLoS ONE 4, e5121(2009)
  • [13] Matsuura, M., Nishihara, H., Onimaru, K., Kokubo, N., Kuraku, S., Kusakabe, R., Okada, N., Kuratani, S., Tanaka. M.* Identification of four Engrailed genes in the Japanese river lamprey, Lethenteron japonicum. Dev.Dyn. 237, 1581-1589 (2008)
  • [14] Tanaka, M., Hale, L. A., Amores, A., Yan, Y.-L., Cresko, W. A., Suzuki, T., Postlethwait, J. H. Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes. Dev.Biol. 281, 227-239 (2005)
  • [15] Tanaka, M.*, Tickle, C. Tbx18 and boundary formation in chick somite and wing development. Dev. Biol. 268, 470-480 (2004)
  • [16] Cole, N., Tanaka, M., Prescott, A. R., Tickle, C. Expression of limb initiation gene and clues to the basis of morphological diversification of three-spine sticklebacks. Curr. Biol. 13, R951-R952 (2003)
  • [17] Tanaka, M.*, Munsterberg, A., Anderson, W. G., Prescott, A. R., Hazon, N., Tickle, C. Fin development in a cartilaginous fish and the origin of vertebrate limbs. Nature 416, 527-531(2002) This paper is evaluated as one of ‘Must read” paper by Faculty of 1000.
  • [18] Schmidt, M., Tanaka, M., Munsterberg, A. Expression of β-catenin in the developing chick myotome is regulated by myogenic signals. Development 127, 4105-4113 (2000)
  • [19] Tanaka, M.*, Cohn, M. J., Ashby, P., Davey, M., Martin, P., Tickle, C. Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationship to polydactyly. Development 127, 4011-4021 (2000)

【主な日本語総説】

  • [1] 田中 幹子「四肢の起源、形態進化のロジックを辿る?エボデボ研究最前線[動物篇]」生物の科学 遺伝 67, 170-177 (2013)
  • [2] 田中 幹子、鬼丸 洸「脊椎動物が体壁に対鰭を獲得するまでの長い道のり」特集:複合適応形質進化の遺伝子基盤 生物科学 63, 166-174 (2012)

【主な著書】

  •  Tanaka, M. and Tickle, C. Fins/limbs in the study of development. In Fins to Limbs. Brian Hall, ed. University of Chicago Press, Chicago. pp65-78(2006)

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