研究成果

【代表論文】

  • [1] Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy, Scientific Reports, 2016, 6, 36478.
  • [2] Shimpei Otsuka, Kentaro Matsumoto, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura. Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia, PLoS ONE, 2015, 10, e0146026.
  • [3] Mai Miura, Kensuke Ito, Maiko Hayashi, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura. The effect of 5-aminolevulinic acid on cytochrome P450-mediated prodrug activation, PLoS ONE, 2015, 10, e0131793.
  • [4] Maiko Hayashi, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura. The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid, PLoS ONE, 2015, 10, e0122351.
  • [5] Kentaro Matsumoto, Yuichiro Hagiya, Yoshio Endo, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura. Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia, Photodiagnosis and Photodynamic Therapy, 2015, 12, 45-51.
  • [6] Urara Ota, Hideo Fukuhara, Masahiro Ishizuka, Fuminori Abe, Chiaki Kawada, Kenji Tamura, Tohru Tanaka, Keiji Inoue, Shun-ichiro Ogura and Taro Shuin. Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker, Molecular and Clinical Oncology, 2015, 3, 797-801.
  • [7] Kohei Yamashita, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura. The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation, FEBS Open Bio, 2014, 4, 347-352.
  • [8] Yuta Sugiyama, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura*. The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis, Oncology Reports, 2014, 31, 1282-1286.
  • [9] Atsushi Shimoyama, Hiroya Watase, Yu Liu, Shun-Ichiro Ogura, Yuichiro Hagiya, Kiwamu Takahashi, Katsushi Inoue, Tohru Tanaka, Yasutoshi Murayama, Eigo Otsuji, Akihiro Ohkubo and Hideya Yuasa. Access to a novel near-infrared photodynamic therapy through the combined use of 5-aminolevulinic acid and lanthanide nanoparticles, Photodiagnosis and Photodynamic Therapy, 2013, 10, 607-614.
  • [10] Keiji Inoue, Urara Ota, Masahiro Ishizuka, Chiaki Kawada, Hideo Fukuhara, Taro Shuin, Ichiro Okura, Tohru Tanaka and Shun-ichiro Ogura. Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors, Photodiagnosis and Photodynamic Therapy, 2013, 10, 484-489.
  • [11] Yuichiro Hagiya, Hideo Fukuhara, Kentaro Matsumoto, Yoshio Endo, Motowo Nakajima, Tohru Tanaka, Ichiro Okura, Atsushi Kurabayashi, Mutsuo Furihata, Keiji Inoue, Taro Shuin and Shun-ichiro Ogura. Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer, Photodiagnosis and Photodynamic Therapy, 2013, 10, 288-295.
  • [12] Tomohisa Hirano, Yuichiro Hagiya, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Kentaro Matsumoto, Katsushi Inoue, Tohru Tanaka, Ichiro Okura and Shun-ichiro Ogura*. Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate, Photodiagnosis and Photodynamic Therapy, 2013, 10, 28-32.
  • [13] Yuichiro Hagiya, Yoshio Endo, Yutaka Yonemura, Kiwamu Takahashi, Masahiro Ishizuka, Fuminori Abe, Tohru Tanaka, Ichiro Okura, Motowo Nakajima, Toshihisa Ishikawa and Shun-ichiro Ogura. Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro, Photodiagnosis and Photodynamic Therapy, 2012, 9, 204-214.
  • [14] Masahiro Ishizuka, Yuichiro Hagiya, Yasuhiro Mizokami, Kanako Honda, Kenji Tabata, Toshiaki Kamachi, Kiwamu Takahashi, Fuminori Abe, Tohru Tanaka, Motowo Nakajima, Shun-ichiro Ogura and Ichiro Okura. Porphyrins in mouse urine after administration of 5-aminolevulinic acid as a potential tumor marker, Photodiagnosis and Photodynamic Therapy, 2011, 8, 328-331.
  • [15] Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, Ichiro Okura, Motowo Nakajima and Tohru Tanaka. The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver, BMC Research Notes, 2011, 4, 66.

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