研究成果

太田 啓之 教授
【代表論文】

葉緑体膜脂質の合成機構、環境応答、植物の進化

  • [1] Primitive Extracellular Lipid Components on the Surface of the Charophytic Alga Klebsormidium flaccidum and Their Possible Biosynthetic Pathways as Deduced from the Genome Sequence. (2016) Kondo S, Hori K, Sasaki-Sekimoto Y, Kobayashi A, Kato T, Yuno-Ohta N, Nobusawa T, Ohtaka K, Shimojima M, Ohta H. Front Plant Sci. 7,952.
  • [2] Tangled evolutionary processes with commonality and diversity in plastidial glycolipid synthesis in photosynthetic organisms. Hori K, Nobusawa T, Watanabe T, Madoka Y, Suzuki H, Shibata D, Shimojima M, Ohta H. (2016) Biochim Biophys Acta. Sep;1861(9 Pt B):1294-308. doi: 10.1016/j.bbalip.2016.04.015. Epub 2016 Apr 21.
  • [3] Manipulation of oil synthesis in Nannochloropsis strain NIES-2145 with a phosphorus starvation-inducible promoter from Chlamydomonas reinhardtii. (2015) Iwai M, Hori K, Sasaki-Sekimoto Y, Shimojima M, Ohta H. Front Microbiol. 6,912.
  • [4] Klebsormidium flaccidum genome reveals primary factors for plant terrestrial adaptation. (2014) Hori K., et al. Nature Communications 53,978.
  • [5] Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. (2009) Nakamura, Y, Koizumi, R, Shui, G, Shimojima, M, Wenk MR, Ito T, Ohta H Proc. Natl. Acad. Sci. USA 106, 20978-20983.
  • [6] Type B monogalactosyldiacylglycerol synthases are involved in phosphate starvation induced lipid remodeling and are crucial for low-phosphate adaptation. (2009) Kobayashi K, Awai K, Nakamura M, Nagatani A, Masuda T, Ohta H. Plant J. 57(2), 322-31.
  • [7] Galactolipid synthesis in chloroplast inner envelope is essential for proper thylakoid biogenesis, photosynthesis, and embryogenesis. (2007) Kobayashi K, Kondo M, Fukuda H, Nishimura M, Ohta H Proc. Natl. Acad. Sci. USA104, 17216-17221.
  • [8] Two types of MGDG synthase genes, found widely in both "16:3" and "18:3" plants, differentially mediate galactolipid syntheses in photosynthetic and non-photosynthetic tissues in Arabidopsis thaliana (2001) Awai K, Marechal E, Block M.A, Brun D, Masuda T, Shimada H, Takamiya K, Ohta H, Joyard J Proc. Natl. Acad. Sci. USA 98, 10960-10965
  • [9] Cloning of the gene for monogalactosyldiacylglycerol synthase and its evolutionary origin (1997) Shimojima M, Ohta H, Iwamatsu A, Masuda T, Shioi Y, Takamiya K Proc. Natl. Acad. Sci. USA 97, 333-337.

植物ホルモン応答、共発現解析

  • [1] ATTED-II: a database of co-expressed genes and cis elements for identifying co-regulated gene groups in Arabidopsis (2007) Obayashi T, Kinoshita K, Nakai K, Shibaoka M, Hayashi S, Saeki M, Shibata D, Saito K, Ohta H Nucl. Acids Res. Database Issue, 863-869.
  • [2] Coordinated activation of metabolic pathways for antioxidants and defense compounds by jasmonates and their roles in stress tolerance in Arabidopsis thaliana (2005) Sasaki-Sekimoto Y, Taki N, Obayashi T, Aono M, Matsumoto F,  Sakurai N, Suzuki H, Y-Hirai M, Noji M, Saito K, Masuda T, Takamiya K, Shibata D, Ohta HPlant J. 44, 653-668.
  • [3] 12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis (2005) Taki N, Sasaki-Sekimoto Y, Obayashi T, Kikuta A, Kobayashi K, Ainai T, Yagi K, Sakurai N, Suzuki H, Masuda T, Takamiya K, Shibata D, Kobayashi Y, Ohta H Plant Physiol.139,1268-1283.

【主な日本語総説】

  • [1] 中村友輝、太田啓之 (2010) 高等植物ホスファチジン酸ホスファターゼの膜脂質合成, シグナリングにおける機能 生化学 Vol 82 (12) 1137-1141.
  • [2] 下嶋美恵、小林康一、太田啓之、 (2008) 葉緑体チラコイド膜を構成するグリセロ糖脂質の生合成と機能 化学と生物 学会出版センター 46, 5, 330-338

【著書】

  • [1] 「植物ホルモンの分子生物学」1.7 ジャスモン酸 関本(佐々木)結子、太田啓之


下嶋 美恵 准教授
【代表論文】

  • [1] An engineered lipid remodeling system using a galactolipid synthase promoter during phosphate starvation enhances oil accumulation in plants. (2015) Shimojima M, Madoka Y, Fujiwara R, Murakawa M, Yoshitake Y, Ikeda K, Koizumi R, Endo K, Ozaki K, Ohta H. Front Plant Sci. 6:664. 日経産業新聞、科学新聞、TBS「未来の起源」で紹介
  • [2] Monogalactosyldiacylglycerol synthesis in the outer envelope membrane of chloroplasts is required for enhanced growth under sucrose supplementation. (2014) Murakawa M, Shimojima M, Shimomura Y, Kobayashi K, Awai K, Ohta H. Front Plant Sci. 5:280.
  • [3] Monogalactosyldiacylglycerol synthesis in the outer envelope membrane of chloroplasts is required for enhanced growth under sucrose supplementation. (Murakawa M, Shimojima M, Shimomura Y, Kobayashi K, Awai K and *Ohta H.) (2014) Front. Plant Sci. 23: 280.
  • [4] Enhancement of extraplastidic oil synthesis in Chlamydomonas reinhardtii using a type-2 diacylglycerol acyltransferase with a phosphorus starvation-inducible promoter. (Iwai M, Ikeda K, Shimojima M and *Ohta H.) (2014) Plant Biotechnol. J. 12: 808-19.日経産業新聞、科学新聞に掲載
  • [5] Cyanobacterial monogalactosyldiacylglycerol-synthesis pathway is involved in normal unsaturation of galactolipids and low-temperature adaptation of Synechocystis sp. PCC 6803. (Yuzawa Y, *Shimojima M, Sato R, Mizusawa N, Ikeda K, Suzuki M, Iwai M, Hori K, Wada H, Masuda S and Ohta H.) (2014) Biochim. Biophys. Acta. 1841: 475-83.
  • [6] Differential regulation of two types of monogalactosyldiacylglycerol synthase in membrane lipid remodeling under phosphate-limited conditions in sesame plants. (Shimojima M, Watanabe T, Madoka Y, Koizumi R, Yamamoto MP, Masuda K, Yamada K, Masuda S and *Ohta H.) (2013) Front. Plant Sci. 4: 469.
  • [7] Temperature-dependent hyper-activation of monoglucosyldiacylglycerol synthase is post-translationally regulated in Synechocystis sp. PCC 6803. (Shimojima M, Tsuchiya M and *Ohta H.) (2009) FEBS Lett. 583: 2372-6.
  • [8] A chloroplastic UDP-glucose pyrophosphorylase from Arabidopsis is the committed enzyme for the first step of sulfolipid biosynthesis. (Okazaki Y, Shimojima M, Sawada Y, Toyooka K, Narisawa T, Mochida K, Tanaka H, Matsuda F, Hirai A, Hirai M Y, Ohta H and *Saito K.) (2009) Plant Cell 21: 892-909. Highly Cited Paper 2014
  • [9] Ferredoxin-dependent glutamate synthase moonlights in plant sulfolipid biosynthesis by forming a complex with SQD1. (Shimojima M, Hoffmann-Benning S, Garavito RM and *Benning C.) (2005) Arch. Biochem. Biophys. 436: 206-214.
  • [10] Native uridine 5(')-diphosphate-sulfoquinovose synthase, SQD1, from spinach purifies as a 250-kDa complex. (Shimojima M and *Benning C.) (2003) Arch. Biochem. Biophys. 413: 123-130.
  • [11] Cloning of the gene for monogalactosyldiacylglycerol synthase and its evolutionary origin. (Shimojima M, Ohta H, Iwamatsu A, Masuda T, Shioi Y and *Takamiya K.) (1997) Proc. Natl. Acad. Sci. USA. 94: 333-337. 日経産業新聞掲載

主な総説

  • [1]  Critical regulation of galactolipid synthesis controls membrane differentiation and remodeling in distinct plant organs and following environmental changes. (Shimojima M and *Ohta H.) (2011) Prog. Lipid Res. 50: 258-66.
  • [2]  Biosynthesis and functions of the plant sulfolipid. (*Shimojima M.) (2011) Prog. Lipid Res. 50: 234-9.
  • [3] 岡咲洋三、下嶋美恵、太田啓之、斎藤和季 (2009) 脂質メタボローム解析でスルホ脂質生合成の鍵となる新規遺伝子を発見 バイオサイエンスとインダストリー JBA 67(7); 342-346.
  • [4] 下嶋美恵、小林康一、太田啓之 (2008) 葉緑体チラコイド膜を構成するグリセロ糖脂質の生合成と機能 化学と生物46(5); 330-338

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