研究成果

【代表論文】

ES細胞・iPS細胞由来肝組織、またはその他の人工肝臓モデル

  • [1] Ogawa, S., *Y. Tagawa, A. Kamiyoshi, A. Suzuki, J. Nakayama, Y. Hashikura, and S. Miyagawa: Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system.  Stem Cells  23:903-913,2005
  • [2] Tsutsui, M., S. Ogawa, Y. Inada, E. Tomioka, A. Kamiyoshi, S. Tanaka, T. Kishida, M. Nishiyama, M. Murakami, J. Kuroda, Y. Hashikura, S. Miyagawa, F. Satoh, N. Shibata, and *Y. Tagawa: Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system.  Drug Metab. Dispos.  34:696-701, 2006
  • [3] Sakai, H., *Y. Tagawa, M. Tamai, H. Motoyama, S. Ogawa, J. Soeda, T. Nakata, S. Miyagawa: Isolation and characterization of portal branch ligation-stimulated Hmga2-positive bipontent hepatic progenitor cells. Biochem. Biophys. Res. Commun. 403:298-304. 2010
  • [4] Tamai, M., A, Yamashita, and *Y. Tagawa: Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells.  J. Biosci. Bioeng. 112:495-500,2011
  • [5] Toyoda, Y., M. Tamai, K. Kashikura, S. Kobayashi, Y. Fujiyama, T. Soga, and *Y. Tagawa: Acetoaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network. Drug Metab. Dispos. 40:169-177, 2012
  • [6] Tamai, M., E. Adachi, and *Y. Tagawa: Characterization of a liver organoid tissue composed of hepatocytes and fibroblast in dense collagen fibrils.  Tissue Engineering part A  19:2527-2535, 2013
  • [7] Shang, Y., M. Tamai, R. Ishii, N. Nagaoka, Y. Yoshida, M. Ogasawara, J. Yang, and *Y. Tagawa: Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells.  J. Biosci. Bioeng. 117:99-106, 2014
  • [8] Ahn, S., M. Tamai, K. Nakashima, M. Ito, T. Suzuki, and *Y. Tagawa: An in vitro liver model consisting of endothelial vascular networks surrounded by human hepatoma cell lines allows for improved hepatitis B virus replication. J. Biosci. Bioeng. in press.

発生工学

  • [1] Tagawa, Y., K. Sekikawa, and Y. Iwakura. : Suppression of concanavalin A-induced hepatitis in IFN-g(-/-) mice, but not in TNF-a(-/-) mice: role for IFN-g in activating apoptosis of hepatocytes. J. Immunol. 159:1418-1428, 1997
  • [2] Yoshimoto, T., H. Okamura, Y. Tagawa, Y. Iwakura, and K. Nakanishi. : Interleukin-18 together with interleukin-12 inhibits IgE production by induction of interferon-g production from activated B cells. Proc. Natl. Acad. Sci. U S A. 94:3948-3953, 1997
  • [3] Shimada, S., M. Kawaguchi-Miyashita, A. Kushiro, T. Sato, M. Nanno, T. Sako, Y. Matsuoka, K. Sudo, Y. Tagawa, Y. Iwakura, and M. Ohwaki. 1999. Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA.  J. Immunol. 163:5367-5373, 1999
  • [4] Tanaka, J., H. Ozaki, J. Yasuda, R. Horai, Y. Tagawa, M. Asano, S. Saijo, M. Imai, K. Sekikawa, M. Kopf, and Y. Iwakura. : Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-g nor interleukin-6. AIDS 14:1299-1307, 2000
  • [5] Denda, K., K. Nkano-Wakabayashi, N. Okamoto, N. Kitamura, J. Ryu, Y. Tagawa, T. Ichisaka, S. Yamanaka, and M. Komada: Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.  J. Biol. Chem.286:28802-28810, 2011
  • [6] Ryu, J.-Y., A. Siswanto, K. Harimoto, and *Y. Tagawa: Chimeric analysis of EGFP and DsRed2 transgenic mice demonstrates polyclonal maintenance of pancreatic acini. Transgenic Res. 22:549-556, 2013
  • [7] Aikawa, H., M. Tamai, K. Mitamura, F. Itmainati, G. N. Barber, and *Y. Tagawa: Innate immunity in an in vitro murine blastocyst model using embryonic and trophoblast stem cells. J. Biosci. Bioeng.117:358-365, 2014

【主な日本語総説】

  • [1] 田川陽一編 創立90周年記念特別企画 特集「こんな研究にもES細胞やiPS細胞が役に立つ -ノックアウトマウス、再生医療、毒性試験だけではない-」 生物工学会誌. 90:546-561, 2012
  • [2] 三田村圭祐、田川陽一:RNaseの豊富な組織からのRNA抽出のコツ 実験医学 30:2641-2647, 2012
  • [3] 田川陽一編 特集「発生工学」 生物工学会誌. 81:343-360, 2003
  • [4] 田川陽一、浅野雅秀、岩倉洋一郎 :遺伝子ノックアウトマウスの作製法.   細胞工学14, 946-955. 1995.

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