研究成果

【代表論文】(占部)

原書論文

  • [1] H. Murase, K. Senda, M. Senoo, T. Hata, and H. Urabe, "Rhodium-catalyzed Intramolecular Hydroarylation of 1-Halo-1-alkynes. Regioselective Synthesis of Semihydrogenated Aromatic Heterocycles," Chem. Eur. J., 20, 317-322 (2014).
  • [2] M. Yamagishi, K. Nishigai, A. Ishii, T. Hata, and H. Urabe, "Facile Preparation of Indoles and 1,2-Benzothiazine 1,1-Dioxides via Nucleophilic Addition of Sulfonamides to Bromoacetylenes Followed by Pd-Catalyzed Cyclization," Angew. Chem. Int. Ed., 51, 6471-6474 (2012).
  • [3] N. Hirone, H. Sanjiki, R. Tanaka, T. Hata, and H. Urabe, "Acceleration of the Substitution of Silanes with Grignard Reagents by Using either LiCl or YCl3/MeLi," Angew. Chem. Int. Ed., 49, 7762-7764 (2010).
  • [4] D. Shikanai, H. Murase, T. Hata, and H. Urabe, "Rh-catalyzed Isomerization and Intramolecular Redox Reaction of Alkynyl Ethers Affording Dihydropyrans and Ketoolefins," J. Am. Chem. Soc., 131, 3166-3167 (2009).
  • [5] S. Okada,† K. Arayama,† R. Murayama, T. Ishizuka, K. Hara, N. Hirone, T. Hata, and H. Urabe, "Iron-Catalyst-Switched Selective Conjugate Addition of Grignard Reagents.  α,β,γ,δ-Unsaturated Amides as Versatile Templates for Asymmetric Three-Component Coupling Process," Angew. Chem. Int. Ed., 47, 6860-6864 (2008).  † Equal contribution
  • [6] R. Tanaka, H. Sanjiki, and H. Urabe, "Yttrium-Mediated Conversion of Vinyl Grignard Reagent to a 1,2-Dimetalated Ethane and Its Synthetic Application," J. Am. Chem. Soc., 130, 2904-2905 (2008).
  • [7] Y. Fukudome, H. Naito, T. Hata, and H. Urabe, "Copper-Catalyzed 1,2-Double Amination of 1-Halo-1-alkynes. Concise Synthesis of Protected Tetrahydropyrazines and Related Heterocyclic Compounds," J. Am. Chem. Soc., 130, 1820-1821 (2008).
  • [8] Y. Nobe, K. Arayama, and H. Urabe, "Air-Assisted Addition of Grignard Reagents to Olefins.  A Simple Protocol for Three-Component Coupling Process Yielding Alcohols," J. Am. Chem. Soc., 127, 18006-18007 (2005).
  • [9] R. Tanaka, A. Yuza, Y. Watai, D. Suzuki, Y. Takayama, F. Sato, and H. Urabe, "One-Pot Synthesis of Metalated Pyridines from Two Acetylenes, a Nitrile, and a Titanium(II) Alkoxide," J. Am. Chem. Soc., 127, 7774-7780 (2005).
  • [10] D. Suzuki, Y. Nobe, Y. Watai, R. Tanaka, Y. Takayama, F. Sato, and H. Urabe, "Facile Preparation of Various Heteroaromatic Compounds via Azatitanacyclopentadiene Intermediates," J. Am. Chem. Soc., 127, 7474-7479 (2005).

【最近の論文】(秦)

  • [1] “Iron-Catalyzed Regio- and Stereoselective Conjugate Addition of Aryl Grignard Reagents to α,β,γ,δ-Unsaturated Sulfones and Its Synthetic Application”
    Takeshi Hata, Takuya Nakada, Oh Yun Taek, Naoki Hirone, and Hirokazu Urabe
    Adv. Synth. Catal. 2013, 355, 1736-1740.
  • [2] “Four Nucleophilic Additions to Alkenynedioic Acid Derivatives in Tandem; Efficient One-pot Synthesis of Bicyclo[4.2.0]octenols”
    Takeshi Hata, Haduki Imade, and Hirokazu Urabe
    Org. Lett. 2012, 14, 2450-2453.
  • [3] “Iron-Catalyzed Synthesis of Allenes from 2-Alken-4-ynoates and Grignard Reagents”
    Takeshi Hata, Satoshi Iwata, Shumpei Seto, and Hirokazu Urabe
    Adv. Synth. Catal. 2012, 354, 1885-1889.
  • [4] “Iron-Mediated and -Catalyzed Metallative Cyclization of Electron Withdrawing Group-substituted Alkynes and Alkenes with Grignard Reagents”
    Takeshi Hata, Shiro Sujaku, Naoki Hirone, Kirihiro Nakano, Junsuke Imoto, Haduki Imade, and Hirokazu Urabe
    Chem.-Eur. J. 2011, 17, 14593-14602.
  • [5] “Iron-Catalyzed Regio- and Stereoselective Substitution of g,d-Epoxy-a,b-unsaturated Esters and Amides with Grignard Reagents”
    Takeshi Hata, Rie Bannai, Mamoru Otsuki, and Hirokazu Urabe
    Org. Lett. 2010, 12, 1012-1014.

【総説など】(占部)

  • [1] 占部、秦、"第4章 芳香族化合物 − 医薬品化学への展開"、生命理工系のための大学院基礎講座 − 有機化学、湯浅英哉・編、東京工業大学出版会・工学図書、pp. 67-90 (2011).
  • [2] H. Urabe and F. Sato, "Titanocene (Cp2Ti(II)" in Encyclopedia of Reagents for Organic Synthesis, 2nd ed.; L. A. Paquette, D. Crich, P. L. Fuchs, G. A. Molander, Eds., Wiley: Chichester, Vol. 12, pp. 9590-9595 (2009).
  • [3] 占部、"メタラサイクルをテンプレートとする多成分連結反応の開発"、化学工業、57, 757-762 (2006).
  • [4] H. Urabe, "New Synthetic Reactions Mediated by Organometallic Compounds" in My Favorite Organic Synthesis, 有機合成化学協会・竜田邦明・福山透編、化学同人、pp. 244-245 (2002).
  • [5] F. Sato, H. Urabe, and S. Okamoto, "Synthesis of Organotitanium Complexes from Alkenes and Alkynes, and Their Synthetic Application," Chem. Rev., 100, 2835-2886 (2000).

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