研究成果

【原著論文】

  • [1] Takashi Hirasawa, Hiroshi Shimizu (2016) Recent advances in amino acid production by microbial cells. Current Opinion in Biotechnology 42:133-146.
  • [2] Yoshohiro Toya, Takashi Hirasawa, Shu Ishikawa, Onuma Chumsakul, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Katsuya Ozaki, Naotake Ogasawara, Hiroshi Shimizu (2015) Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis. Bioscience, Biotechnology, and Biochemistry 79:2073-2080.
  • [3] Yuto Yamauchi, Takashi Hirasawa, Masato Nishii, Chikara Furusawa, Hiroshi Shimizu (2014) Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB. Journal of General and Applied Microbiology 60:112-118.
  • [4] Kento Tokuyama, Satoshi Ohno, Katsunori Yoshikawa, Takashi Hirasawa, Shotaro Tanaka, Chikara Furusawa, Hiroshi Shimizu (2014) Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microbial Cell Factories 13:64
  • [5] Yuma Ito, Takashi Hirasawa, Hiroshi Shimizu (2014) Metabolic engineering of Saccharomyces cerevisiae for improving succinic acid production based on metabolic profiling. Bioscience, Biotechnology, and Biochemistry 78:151-159.
  • [6] Yuki Usui, Takashi Hirasawa, Chikara Furusawa, Tomokazu Shirai, Natsuko Yamamoto, Hirotada Mori, Hiroshi Shimizu (2012) Investigating the effects of perturbations to pgi and eno gene expression on central carbon metabolism in Escherichia coli using 13C metabolic flux analysis. Microbial Cell Factories 11:87.
  • [7] Jongpill Kim, Hirohisa Fukuda, Takashi Hirasawa, Keisuke Nagahisa, Kazuo Nagai, Masaaki Wachi, Hiroshi Shimizu (2010) Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum. Applied Microbiology and Biotechnology 86:911-920.
  • [8] Nobuyoshi Ishii#, Kenji Nakahigashi#, Tomoya Baba#, Martin Robert#, Tomoyoshi Soga#, Akio Kanai#, Takashi Hirasawa#, Miki Naba, Kenta Hirai, Aminul Hoque, Pei Yee Ho, Yuji Kakazu, Kaori Sugawara, Saori Igarashi, Satoshi Harada, Takeshi Masuda, Naoyuki Sugiyama, Takashi Togashi, Miki Hasegawa, Yuki Takai, Katsuyuki Yugi, Kazuharu Arakawa, Nayuta Iwata, Yoshihiro Toya, Yoichi Nakayama, Takaaki Nishioka, Kazuyuki Shimizu, Hirotada Mori, Masaru Tomita (2007) Multiple high throughput analyses monitor the response of E. coli to perturbations. Science 316:593-597. (#Equally contributed)
  • [9] Takashi Hirasawa, Katsunori Yoshikawa, Yuki Nakakura, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Hiroshi Shimizu, Suteaki Shioya (2007) Identification of target genes for conferring ethanol stress-tolerance to yeast Saccharomyces cerevisiae based on DNA microarray data analysis. Journal of Biotechnology 131:33-44.
  • [10] Takashi Hirasawa, Masaaki Wachi, Kazuo Nagai (2000) A mutation in the Corynebacterium glutamicum ltsA gene causes susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production. Journal of Bacteriology 182:2696-2701.

【著書】

  • [1] Takashi Hirasawa, Hiroshi Shimizu (2013) Glutamic acid. In Bioprocessing of renewable resources to commodity bioproducts. Virendra S. Bisaria and Akihiko Kondo (eds), Wiley (in press)
  • [2] Takashi Hirasawa, Jongpill Kim, Tomokazu Shirai, Chikara Furusawa, Hiroshi Shimizu (2012) Molecular mechanisms and metabolic engineering of glutamate overproduction in Corynebacterium glutamicum. In Subcellular Biochemistry, Volume 64, Reprogramming Microbial Metabolic Pathways. Xiaoyuan Wang, Jian Chen and Peter J. Quinn (eds), Springer. pp. 261-281.
  • [3] 平沢 敬 (2008) ベーシックマスター生化学「第9章 クエン酸回路と電子伝達系」大山 隆監修 西川一八・清水光弘共編 オーム社
  • [4] Hiroshi Shimizu, Takashi Hirasawa. (2007) Production of glutamate and glutamate-related amino acids: Molecular mechanism analysis and metabolic engineering. In Microbiology Monograph. Volume 5. Amino acid biosynthesis-pathways, regulation and metabolic engineering. Volker F. Wendisch (ed), Springer. pp 1-38.

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