研究成果

【代表論文】

  • [1] Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Sawada H, Takahashi J, Takahashi R, Inoue H. Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders. Hum Mol Genet, (in press)
  • [2] Kawahata I, Ohtaku S, Tomioka Y, Ichinose H, Yamakuni T. (2015) Dopamine or biopterin deficiency potentiates phosphorylation at Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system. Biochem Biophys Res Commun 465: 53-58.
  • [3] Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda SI, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H (2014) Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse. FEBS Lett 588: 3924-3931
  • [4] Liang Y, Inagaki H, Hao Q, Sakamoto M, Ohye T, Suzuki T, Ichinose H (2013) Identification of an enhancer region for immune activation in the human GTP cyclohydrolase I gene. Biochem Biophys Res Commun 442: 72-78
  • [5] Homma D, Katoh S, Tokuoka H, Ichinose H (2013) The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain. J Neurochem 126: 70-81
  • [6] Toda T, Homma D, Tokuoka H, Hayakawa I, Sugimoto Y, Ichinose H, Kawasaki H (2013) Birth regulates the initiation of sensory map formation through serotonin signaling. Dev Cell 27: 32-46
  • [7] Tokuoka H, Muramatsu S, Sumi-Ichinose C, Sakane H, Kojima M, Aso Y, Nomura T, Metzger D, Ichinose H (2011) Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem 286: 43549-43558
  • [8] Koshiba S, Tokuoka H, Yokoyama T, Horiuchi E, Ichinose H, Hasegawa K (2011) Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T). J Neural Transm 118: 899-903
  • [9] Homma D, Sumi-Ichinose C, Tokuoka H, Ikemoto K, Nomura T, Kondo K, Katoh S, Ichinose H (2011) Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain. J Biol Chem 286: 1445-1452
  • [10] Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Bjorklund A, Ichinose H, Perlmann T (2009) Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci 29: 15923-15932
  • [11] Sato K, Sumi-Ichinose C, Kaji R, Ikemoto K, Nomura T, Nagatsu I, Ichinose H, Ito M, Sako W, Nagahiro S, Graybiel AM, Goto S (2008) Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia. Proc Natl Acad Sci USA 105: 12551-12556
  • [12] Suzuki T, Yamakuni T, Hagiwara M, Ichinose H (2002) Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. J Biol Chem 277: 40768-40774
  • [13] Sumi-Ichinose C, Urano F, Kuroda R, Ohye T, Kojima M, Tazawa M, Shiraishi H, Hagino Y, Nagatsu T, Nomura T, Ichinose H (2001) Catecholamines and serotonin are differently regulated by tetrahydrobiopterin: a study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem 276: 41150-41160

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