研究成果

徳永 万喜洋 教授
【代表論文】 

  • [1] Ito Y, Sakata-Sogawa K, Tokunaga M.: A Facile Preparation of Glass-supported Lipid Bilayers for Analyzing Molecular Dynamics.: Anal Sci, 30 (12), 1103-1106, 2014. PMID: 25492457 selected as Hot Article Award
  • [2] Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H:: Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516 (7530), 272-275, 2014.
  • [3] Yokosuka T., Kobayashi W., Takamatsu M., Sakata-Sogawa K., Zeng H., Hashimoto-Tane A., Yagita H., Tokunaga M., Saito T.: Spatiotemporal basis of ctla-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity 33, (3) 326-339, 2010. PMID: 20870175
  • [4] Shiina N, Yamaguchi K, Tokunaga M.: RNG105 Deficiency Impairs the Dendritic Localization of mRNAs for Na+/K+ ATPase Subunit Isoforms and Leads to the Degeneration of Neuronal Networks. J. Neuroscience, 30 (38), 12816-12830, 2010. PMID: 20861386
  • [5] Fukagawa A., Hiroshima M., Sakane I., Tokunaga M.: Stochastic emergence of multiple intermediates detected by single-molecule quasi-static mechanical unfolding of protein., BIOPHISICS 5, 25-35, 2009.
  • [6] Yokosuka T., Kobayashi W., Sakata-Sogawa K., Takamatsu M., Hashimoto-Tane A., Dustin ML., Tokunaga M., Saito T.: Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity, 29(4), 589-601, 2008. PMID:18848472
  • [7] Tokunaga M., Imamoto N., Sakata-Sogawa K.: Highly inclined thin illumination enables clear single-molecule imaging in cells. Nat Methods, 5(2), 159-161, 2008. PMID:18176568
  • [8] Yamasaki S., Sakata-Sogawa K., Hasegawa A., Suzuki T., Kabu K., Sato E., Kurosaki T., Yamashita S., Tokunaga M., Nishida K., Hirano T.: Zinc is a novel intracellular second messenger. J. Cell. Biol., 177(4), 637-645, 2007. PMID:17502426
  • [9] Yamasaki S., Ishikawa E., Sakuma M., Ogata K., Sakata-Sogawa K., Hiroshima M., Wiest DL., Tokunaga M., Saito T.: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat. Immunol., 7(1), 67-75, 2006. PMID:16327787
  • [10] Shiina N., Shinkura K., Tokunaga M.: A novel RNA-binding protein in neuronal RNA granules: Regulatory machinery for local translation. J.Neuroscience, 25 (17), 4420-4434, 2005.
  • [11] Yanagida T., Esaki S., Iwane A.H., Inoue Y., Ishijima A., Kitamura K., Tanaka H., Tokunaga M.: Single-motor mechanics and models of the myosin motor. Philos. Trans. R. Soc. Lond. B Biol Sci, 355, 441-447, 2000.
  • [12] Kitamura K., Tokunaga M., Iwane A. H. & Yanagida T.: A single myosin head moves along an actin filament with regular steps of 5.3 nanometres. Nature, 397, 129-134, 1999.

十川 久美子 准教授
【代表論文】 

  • [1] Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, and *Kimura H.: Regulation of RNA polymerase II activation by histone acetylation in single living cells. Nature 516, 272–275 (2014)
  • [2] Ito Y., *Sakata-Sogawa K., *Tokunaga M.: A facile preparation of glass-supported lipid bilayers for analyzing molecular dynamics. Analytical Sciences 30 (12), 1103-1106 (2014)
  • [3] Yamazaki S., Yamamoto K., Tokunaga M., Sakata-Sogawa K., * Harata M.: Nuclear actin activates human transcription factor genes including the eOCT4 g. Biosci Biotechnol Biochem 2014. Ct 30 1-5. DOI:10.1080/09168451.2014.972332
  • [4] Asakawa H, Yang HJ, Yamamoto TG, Ohtsuki C, Chikashige Y, Sakata-Sogawa K, Tokunaga M, Iwamoto M, Hiraoka Y, *Haraguchi T: Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe. Nucleus 5 (2) 1-14 (2014)
  • [5] Hotta K, Nashimoto A., Yasumura E., Suzuki M., Azuma M., Iizumi Y., Shima D., Nabeshima R., Hiramoto M., Okada A., Sakata-Sogawa K., Tokunaga M., Ito T., Ando H., Sakamoto S., Kabe Y., Aizawa S., Imai T., Yamaguchi Y., Watanabe H., *Handa H.: Vesnarinone Suppresses TNFa mRNA Expression by Inhibiting Valosin-containing Protein. Mol Pharmacol, 83, (5) 930-938 (2013)
  • [6] Hashimoto-Tane A. ,Yokosuka T., Sakata-Sogawa K., Sakuma M., Ishihara C., Tokunaga M., *Saito T.: Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation. Immunity, 34, 919-931 (2011)
  • [7] Yokosuka T., Kobayashi W., Takamatsu M., Sakata-Sogawa K., Zeng H., Hashimoto-Tane A., Yagita H., Tokunaga M., *Saito T.: Spatiotemporal basis of ctla-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity 33, (3) 326-339 (2010)
  • [8] Yokosuka T., Kobayashi W., Sakata-Sogawa K., Takamatsu M., Hashimoto-Tane A., Dustin ML., Tokunaga M., and *Saito T.: Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase CθTranslocation. Immunity 29, 589-601 (2008)
  • [9] *Tokunaga, M., Imamoto, N., Sakata-Sogawa, K.: Highly inclined thin illumination enables clear single-molecule imaging in cells. Nature Methods. 5, (2) 159-161 (2008)
  • [10] Yamasaki, S., Sakata-Sogawa, K., Hasegawa, A., Suzuki, T., Kabu, K., Sato, E., Kurosaki, T., Yamashita, S., Tokunaga, M., Nishida, K., *Hirano, T.: Zinc is a novel second messenger. J. Cell Biol. 177, 637-645 (2007)
  • [11] Yamasaki S., Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa K., Hiroshima, M., Wiest, D. L., Tokunaga M., *Saito, T.: Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nature Immunol. 7, 67-75 (2006)
  • [12] Yokosuka T., Sakata-Sogawa K., Kobayashi, W., Hiroshima, M., Hashimoto-Tane, A., Tokunaga M., Dustin, M. L., *Saito, T.: Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005)
  • [13] Sakata-Sogawa, K., *Shimamoto, N.: RNA polymerase can track a DNA groove during promoter search. Proc. Natl. Acad. Sci. USA 101(41), 14731-14735 (2004)
  • [14] *Sakata-Sogawa K, Kurachi M, Sogawa K, Fujii-Kuriyama Y, Tashiro H.: Direct measurement of DNA molecular length in solution using optical tweezers: detection of looping due to binding protein interactions. Eur Biophys J. 27(1):55-61.(1998)

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