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| STAFF |
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Visiting Associate Prof. : Junji YAMAUCHI |
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| Research |
| Using the in vitro unique, mammalian neuronal-glial cell co-culture system, we try to investigate the really, mature ‘adult neuronal tissues’of central and peripheral nervous systems. During this study, you can find so many exiting things, such as new cellular signaling pathways and new developmental mechanisms, as well as new therapeutic methods for Alzheimer’s disease and Charcot-Marie-Tooth disease. |
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| @To clarify the molecular mechanism of the peripheral nerve development Figure 1 shows myelin (red) formation of sensory neurons (green) by Schwann cells in co-cultures. This myelin is structurally equivalent to the real myelin of sciatic nerves (Figure 2). We now identify new signaling molecules underlying the peripheral nervous system development, for example, see Figure 3. |
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Figure 1
The in vitro formation of the peripheral nervous tissue |
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Figure 2
The electron microscope photograph of the Figure 1’s sample |
Figure 3
Dock7, the newly-identified gene controlling the peripheral nervous tissue formation |
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| Figure 4 shows the in vitro formation of the spinal cord. If you can make perfect spinal cord or brain tissues, you will be very happy in the future! That’s why you are aging day by day?? |
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Figure 4
The in vitro formation of the central nervous tissue |
| Recent Paper |
| 1) |
Miyamoto, Y. and Yamauchi, J. (2009) Cellular signaling of Dock family proteins in neural cells. Cell. Signal. (review) in press |
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Miyamoto, Y.,Yamauchi, J., and Tanoue, A. (2008) Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. J, Neurosci. in press |
| 3) |
Yamauchi,J., Miyamoto, Y., Chan, J. R., and Tanoue, A. (2008) ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J. Cell Biol. 181, 351-365 |
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